The dosimetric parameters impact on local recurrence in stereotactic radiotherapy for brain metastases.

ABSTRACT:

Objectives

Stereotactic radiotherapy (SRT) for brain metastases (BM) allows very good local control (LC). However, approximately 20%-30% of these lesions will recur. The objective of this retrospective study was to evaluate the impact of dosimetric parameters on LC in cerebral SRT.

Methods

Patients treated with SRT for 1-3 BM between January 2015 and December 2018 were retrospectively included. A total of 349 patients with 538 lesions were included. The median gross tumour volume (GTV) was 2 cm3 (IQR, 0-7). The median biological effective dose with α/β = 10 (BED10) was 60 Gy (IQR, 32-82). The median prescription isodose was 71% (IQR, 70-80). Correlations with LC were examined using the Cox regression model.

Results

The median follow-up period was 55 months (min-max, 7

SUBMITTER: Berthet C 

PROVIDER: S-EPMC11025672 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature