Antithrombotic strategies for preventing graft failure in coronary artery bypass graft.

ABSTRACT: Coronary artery bypass graft (CABG) procedures face challenges related to graft failure, driven by factors such as acute thrombosis, neointimal hyperplasia, and atherosclerotic plaque formation. Despite extensive efforts over four decades, the optimal antithrombotic strategy to prevent graft occlusion while minimizing bleeding risks remains uncertain, relying heavily on expert opinions rather than definitive guidelines. To address this uncertainty, we conducted a review of randomized clinical trials and meta-analyses of antithrombotic therapy for patients with CABG. These studies examined various antithrombotic regimens in CABG such as single antiplatelet therapy (aspirin or P2Y₁₂ inhibitors), dual antiplatelet therapy, and anticoagulation therapy. We evaluated outcomes includin

SUBMITTER: Mauro MS 

PROVIDER: S-EPMC11026197 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature