TusDCB, a sulfur transferase complex involved in tRNA modification, contributes to UPEC pathogenicity.

ABSTRACT: tRNA modifications play a crucial role in ensuring accurate codon recognition and optimizing translation levels. While the significance of these modifications in eukaryotic cells for maintaining cellular homeostasis and physiological functions is well-established, their physiological roles in bacterial cells, particularly in pathogenesis, remain relatively unexplored. The TusDCB protein complex, conserved in γ-proteobacteria like Escherichia coli, is involved in sulfur modification of specific tRNAs. This study focused on the role of TusDCB in the virulence of uropathogenic E. coli (UPEC), a bacterium causing urinary tract infections. The findings indicate that TusDCB is essential for optimal production of UPEC's virulence factors, including type 1 fimbriae and flagellum, impacting the bac

SUBMITTER: Sato Y 

PROVIDER: S-EPMC11026471 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature