Comparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing.

ABSTRACT:

Objectives

To compare brain MRI measures between Adult Changes in Thought (ACT) participants who underwent research, clinical, or both MRI scans, and clinical health measures across the groups and non-MRI subjects.

Methods

Retrospective cohort study leveraging MRI, clinical, demographic, and medication data from ACT. Three neuroradiologists reviewed MRI scans using NIH Neuroimaging Common Data Elements (CDEs). Total brain and white matter hyperintensity (WMH) volumes, clinical characteristics, and outcome measures of brain and overall health were compared between groups. 1166 MRIs were included (77 research, 1043 clinical, and 46 both) and an additional 3146 participants with no MRI were compared.

Results

Compared to the group with research MRI only, the clinical MRI

SUBMITTER: Mossa-Basha M 

PROVIDER: S-EPMC11027291 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature