Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis.

ABSTRACT:

Objective

Tumour progression drives profound alterations in host metabolism, such as adipose tissue depletion, an early event of cancer cachexia. As fatty acid consumption by cancer cells increases upon acidosis of the tumour microenvironment, we reasoned that fatty acids derived from distant adipose lipolysis may sustain tumour fatty acid craving, leading to the adipose tissue loss observed in cancer cachexia.

Methods

To evaluate the pro-lipolytic capacities of acid-exposed cancer cells, primary mouse adipocytes from subcutaneous and visceral adipose tissue were exposed to pH-matched conditioned medium from human and murine acid-exposed cancer cells (pH 6.5), compared to naive cancer cells (pH 7.4). To further address the role of tumoral acidosis on adipose tissue loss, a p

SUBMITTER: Lefevre C 

PROVIDER: S-EPMC11027574 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature