Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells.

ABSTRACT: IL6 is an inflammatory cytokine with pleiotropic functions in both immune and nonimmune cells, and its expression level is inversely correlated with disease prognosis in patients with cancer. However, blocking IL6 alone has only yielded minimal efficacy in human cancer patients. We aimed at defining IL6 expression profiles under inflammatory conditions and cancer, and elucidating the mechanism underlying IL6 intrinsic signaling in colon carcinoma. We report here that colonic inflammation induces IL6 expression primarily in the CD11b⁺Ly6G⁺Ly6C^lo polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) in colon. Although both tumor cells, T cells and myeloid cells all express IL6, PMN-MDSCs are the primary cell type that express IL6 in colon carcinoma, s

SUBMITTER: Ibrahim ML 

PROVIDER: S-EPMC11027602 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature