Knocking out matrix metalloproteinase 12 causes the accumulation of M2 macrophages in intestinal tumor microenvironment of mice.

ABSTRACT: MMP12 is mainly secreted by macrophages, is involved in macrophage development, and decomposes the extracellular matrix. Herein, we investigated whether macrophages would change in the intestinal tumor microenvironment after MMP12 knockout. Apc^Min/+;MMP12^-/-mice were obtained by crossbreeding Apc^Min/+ mice with MMP12 knockout mice (MMP12^-/- mice). The data showed that the number and volume of intestinal tumors were significantly increased in Apc^Min/+;MMP12^-/- mice compared with Apc^Min/+ mice. Additionally, the tumor biomarkers CA19-9, CEA, and β-catenin appeared relatively early in intestinal tumors in Apc^Min/+;MMP12^-/- mice. The results demonstrated that knocking out MMP12 accelerated the tu

SUBMITTER: Yang M 

PROVIDER: S-EPMC11027638 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature