PD-L1 expression correlates with tumor-infiltrating lymphocytes and better prognosis in patients with HPV-negative head and neck squamous cell carcinomas.

ABSTRACT:

Introduction

The importance of immune tumor microenvironment in the prognosis of patients with head and neck squamous carcinomas (HNSCC) is increasingly recognized. We analyzed the prognostic relevance of PD-L1 and PD-1 expressions in relation to the infiltration by CD8⁺ and FOXP3⁺ tumor-infiltrating lymphocytes (TILs).

Methods

Samples from 372 surgically treated HPV-negative HNSCC patients were evaluated by immunohistochemistry for PD-L1 expression [both tumor proportion score (TPS) and combined proportion score (CPS)], PD-1 expression in immune cells, and density of infiltrating CD8⁺ and FOXP3⁺ TILs. PD-L1 expression and CD8⁺ TIL density were combined to establish the type of tumor microenvironment.

Results

29.5

SUBMITTER: Sanchez-Canteli M 

PROVIDER: S-EPMC11027666 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature