CCR8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer.

ABSTRACT: Regulatory T cells (Tregs) play a major role in the development of an immunosuppressive tumor microenvironment. Systemic Treg depletion is not favored because of the critical role of Tregs in maintaining immune homeostasis and preventing the autoimmunity. Recently, CCR8 has been identified as an important chemokine receptor expressed on intratumoral Tregs and is known to be critical for CCR8⁺Treg-mediated immunosuppression. However, the inherent molecular mechanisms and clinical significance of intratumoral CCR8⁺Tregs remain poorly understood. In this study, a retrospective analysis of 259 muscle-invasive bladder cancer (MIBC) patients from two independent clinic centers was conducted to explore the prognostic merit of CCR8⁺Tregs via immunohistochemistry. E

SUBMITTER: Wang T 

PROVIDER: S-EPMC11027714 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature