Clostridium butyricum isolated from giant panda can attenuate dextran sodium sulfate-induced colitis in mice.

ABSTRACT:

Objective

Probiotics are beneficial to the intestinal barrier, but few studies have investigated probiotics from giant pandas. This study aims to explore the preventive effects of giant panda-derived Clostridium butyricum on dextran sodium sulfate (DSS)-induced colitis in mice.

Methods

Clostridium butyricum was administered to mice 14 days before administering DSS treatment to induce enteritis.

Results

Clostridium butyricum B14 could more effectively prevent colitis in mice than C. butyricum B13. C. butyricum B14 protected the mouse colon by decreasing the histology index and serum interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels, which improved intestinal inflammation-related symptoms. In addition, the treatment l

SUBMITTER: Yu S 

PROVIDER: S-EPMC11027743 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature