Analysis of SIRT1 genetic variants in young Mexican individuals: relationships with overweight and obesity.

ABSTRACT: The high prevalence of obesity in Mexico starting from the early stages of life is concerning and represents a major public health problem. Genetic association studies have reported that single nucleotide variants (SNVs) in SIRT1, an NAD^+-dependent deacetylase that plays an important role in the regulation of metabolic cellular functions, are associated with multiple metabolic disorders and the risk of obesity. In the present study, we analyzed the effect that the SNVs rs1467568 and rs7895833 of the SIRT1 gene may have on cardiometabolic risk factors in a young adult population from Mexico. A cross-sectional study was carried out with young adults between the ages of 18 and 25 who had a body mass index (BMI) greater than 18.5 kg/m². This study included 1

SUBMITTER: Salazar-Garcia S 

PROVIDER: S-EPMC11027998 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature