Establishment of adoptive cell therapy with tumor infiltrating lymphocytes for non-small cell lung cancer patients.

ABSTRACT: Adoptive cell therapy (ACT) of tumor infiltration lymphocytes (TIL) yields promising clinical results in metastatic melanoma patients, who failed standard treatments. Due to the fact that metastatic lung cancer has proven to be susceptible to immunotherapy and possesses a high mutation burden, which makes it responsive to T cell attack, we explored the feasibility of TIL ACT in non-small cell lung cancer (NSCLC) patients. Multiple TIL cultures were isolated from tumor specimens of five NSCLC patients undergoing thoracic surgery. We were able to successfully establish TIL cultures by various methods from all patients within an average of 14 days. Fifteen lung TIL cultures were further expanded to treatment levels under good manufacturing practice conditions and functionally and phenotypical

SUBMITTER: Ben-Avi R 

PROVIDER: S-EPMC11028292 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature