Circulating CD8⁺ T-cell repertoires reveal the biological characteristics of tumors and clinical responses to chemotherapy in breast cancer patients.

ABSTRACT:

Purpose

CD8⁺ T cells are primarily cytotoxic cells that provide immunological protection against malignant cells. Considerable evidence suggests that the T-cell repertoire is closely associated with the host immune response and the development of cancer. In this study, we explored the characteristics of the circulating CD8⁺ T-cell repertoire and their potential value in predicting the clinical response of breast cancer patients to chemotherapy.

Experimental design

We applied a high-throughput TCR β-chain sequencing method to characterize the CD8⁺ T-cell repertoire of the peripheral blood from 26 breast cancer patients. In addition, changes in the circulating CD8⁺ T-cell repertoire during chemotherapy were analyzed.

Results

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SUBMITTER: Lin KR 

PROVIDER: S-EPMC11028329 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature