Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy.

ABSTRACT: Limitations of immunotherapy include poorly functioning events early in the immune response cycle, such as efficient antigen presentation and T cell priming. CD40 signaling in dendritic cells leads to upregulation of cell surface costimulatory and MHC molecules and the generation of cytokines, which promotes effective priming of CD8⁺ effector T cells while minimizing T cell anergy and the generation of regulatory T cells. This naturally occurs through interaction with CD40 ligand (CD40L) expressed on CD4⁺ T-helper cells. CD40 signaling can also be achieved using specific antibodies, leading to several agonist CD40 antibodies entering clinical development. Our approach to select a CD40 agonist antibody was to define a balanced profile between sufficiently strong immune

SUBMITTER: Vitale LA 

PROVIDER: S-EPMC11028348 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature