Immune modulation associated with vascular endothelial growth factor (VEGF) blockade in patients with glioblastoma.

ABSTRACT:

Background

Vascular endothelial growth factor (VEGF), in addition to being pro-angiogenic, is an immunomodulatory cytokine systemically and in the tumor microenvironment. We previously reported the immunomodulatory effects of radiation and temozolomide (TMZ) in newly diagnosed glioblastoma. This study aimed to assess changes in peripheral blood mononuclear cell (PBMC) populations, plasma cytokines, and growth factor concentrations following treatment with radiation, TMZ, and bevacizumab (BEV).

Methods

Eleven patients with newly diagnosed glioblastoma were treated with radiation, TMZ, and BEV, following surgery. We measured immune-related PBMC subsets using multi-parameter flow cytometry and plasma cytokine and growth factor concentrations using electrochemiluminescence-based

SUBMITTER: Thomas AA 

PROVIDER: S-EPMC11028819 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature