Protocol for a magnetic resonance imaging study of participants in the fever RCT: Does fever control prevent brain injury in malaria?

ABSTRACT:

Background

Despite eradication efforts, ~135,000 African children sustained brain injuries as a result of central nervous system (CNS) malaria in 2021. Newer antimalarial medications rapidly clear peripheral parasitemia and improve survival, but mortality remains high with no associated decline in post-malaria neurologic injury. A randomized controlled trial of aggressive antipyretic therapy with acetaminophen and ibuprofen (Fever RCT) for malarial fevers being conducted in Malawi and Zambia began enrollment in 2019. We propose to use neuroimaging in the context of the RCT to further evaluate neuroprotective effects of aggressive antipyretic therapy.

Methods

This observational magnetic resonance imaging (MRI) ancillary study will obtain neuroimaging and neurodevelopmental an

SUBMITTER: Chilombe MB 

PROVIDER: S-EPMC11029645 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature