Evaluating the efficacy and safety of Alzheimer's disease drugs: A meta-analysis and systematic review.

ABSTRACT:

Background

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Dementia severity was assessed mainly through cognitive function, psychobehavioral symptoms, and daily living ability. Currently, there are not many drugs that can be selected to treat mild to moderate AD, and the value of drugs remains controversial.

Objective

The aim of this study is to quantitatively evaluate the efficacy and safety of cholinesterase inhibitors (ChEIs), memantine, and sodium oligomannate (GV-971) in the treatment of patients with AD. Additionally, molecular docking analysis will be used to investigate the binding affinities of donepezil, galantamine, rivastigmine, and memantine with key receptor proteins associated with AD, including beta-amyloid (Abeta), microtubule-associat

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11029996 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature