Differential Serum Levels of CACNA1C, Circadian Rhythm and Stress Response Molecules in Subjects with Bipolar Disorder: Associations with Genetic and Clinical Factors.

ABSTRACT:

Background

Many patients with bipolar disorder (BD) do not respond to or have difficulties tolerating lithium and/or other mood stabilizing agents. There is a need for personalized treatments based on biomarkers in guiding treatment options. The calcium voltage-gated channel CACNA1C is a promising candidate for developing personalized treatments. CACNA1C is implicated in BD by genome-wide association studies and several lines of evidence suggest that targeting L-type calcium channels could be an effective treatment strategy. However, before such individualized treatments can be pursued, biomarkers predicting treatment response need to be developed.

Methods

As a first step in testing the hypothesis that CACNA1C genotype is associated with serum levels of CACNA1C, we conducted

SUBMITTER: Allen O 

PROVIDER: S-EPMC11030295 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature