Glia-derived secretory fatty acid binding protein Obp44a regulates lipid storage and efflux in the developing <i>Drosophila</i> brain.

ABSTRACT: Glia derived secretory factors play diverse roles in supporting the development, physiology, and stress responses of the central nervous system (CNS). Through transcriptomics and imaging analyses, we have identified Obp44a as one of the most abundantly produced secretory proteins from Drosophila CNS glia. Protein structure homology modeling and Nuclear Magnetic Resonance (NMR) experiments reveal Obp44a as a fatty acid binding protein (FABP) with a high affinity towards long-chain fatty acids in both native and oxidized forms. Further analyses demonstrate that Obp44a effectively infiltrates the neuropil, traffics between neuron and glia, and is secreted into hemolymph, acting as a lipid chaperone and scavenger to regulate lipid and redox homeostasis in the developing brain. In agreem

SUBMITTER: Yin J 

PROVIDER: S-EPMC11030299 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature