Optimization of ¹H MR spectroscopy methods for large volume acquisition of low concentration downfield resonances at 3T and 7T.

ABSTRACT:

Purpose

This goal of this study was to optimize spectrally selective ¹H MRS methods for large volume acquisition of low concentration metabolites with downfield resonances at 7T and 3T, with particular attention paid to detection of nicotinamide adenine dinucleotide (NAD⁺) and tryptophan.

Methods

Spectrally selective excitation was used to avoid magnetization transfer effects with water, and various sinc pulses were compared to a pure-phase E-BURP pulse. Localization using a single slice selective pulse was compared to voxel-based localization that used three orthogonal refocusing pulses, and low bandwidth refocusing pulses were used to take advantage of the chemical shift displacement of water. A technique for water sideband removal was added, and a me

SUBMITTER: Wilson NE 

PROVIDER: S-EPMC11030301 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature