Spatial motifs reveal patterns in cellular architecture of complex tissues.

ABSTRACT: Spatial organization of cells is crucial to both proper physiological function of tissues and pathological conditions like cancer. Recent advances in spatial transcriptomics have enabled joint profiling of gene expression and spatial context of the cells. The outcome is an information rich map of the tissue where individual cells, or small regions, can be labeled based on their gene expression state. While spatial transcriptomics excels in its capacity to profile numerous genes within the same sample, most existing methods for analysis of spatial data only examine distribution of one or two labels at a time. These approaches overlook the potential for identifying higher-order associations between cell types - associations that can play a pivotal role in understanding development and functi

SUBMITTER: Samadi Z 

PROVIDER: S-EPMC11030378 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature