Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.

ABSTRACT: In many neurological conditions, early-stage neural circuit adaption can preserve relatively normal behaviour. In some diseases, spinal motoneurons progressively degenerate yet movement is initially preserved. We therefore investigated whether these neurons and associated microcircuits adapt in a mouse model of progressive motoneuron degeneration. Using a combination of in vitro and in vivo electrophysiology and super-resolution microscopy, we found that, early in the disease, neurotransmission in a key pre-motor circuit, the recurrent inhibition mediated by Renshaw cells, is reduced by half due to impaired quantal size associated with decreased glycine receptor density. This impairment is specific, and not a widespread feature of spinal inhibitory circuits. Furthermore, it r

SUBMITTER: Nascimento F 

PROVIDER: S-EPMC11030447 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature