Associations between structural brain changes and blood neurofilament light chain protein in treatment-resistant schizophrenia.

ABSTRACT:

Background and hypothesis

Around 30% of people with schizophrenia are refractory to antipsychotic treatment (treatment-resistant schizophrenia; TRS). While abnormal structural neuroimaging findings, in particular volume and thickness reductions, are often observed in schizophrenia, it is anticipated that biomarkers of neuronal injury like neurofilament light chain protein (NfL) can improve our understanding of the pathological basis underlying schizophrenia. The current study aimed to determine whether people with TRS demonstrate different associations between plasma NfL levels and regional cortical thickness reductions compared with controls.

Study design

Measurements of plasma NfL and cortical thickness were obtained from 39 individuals with TRS, and 43 healthy controls. T

SUBMITTER: Cilia BJ 

PROVIDER: S-EPMC11030485 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature