Circadian protein expression patterns in healthy young adults.

ABSTRACT:

Objectives

To explore how the blood plasma proteome fluctuates across the 24-hour day and identify a subset of proteins that show endogenous circadian rhythmicity.

Methods

Plasma samples from 17 healthy adults were collected hourly under controlled conditions designed to unmask endogenous circadian rhythmicity; in a subset of 8 participants, we also collected samples across a day on a typical sleep-wake schedule. A total of 6916 proteins were analyzed from each sample using the SomaScan aptamer-based multiplexed platform. We used differential rhythmicity analysis based on a cosinor model with mixed effects to identify a subset of proteins that showed circadian rhythmicity in their abundance.

Results

One thousand and sixty-three (15%) proteins exhibited significant dai

SUBMITTER: Specht A 

PROVIDER: S-EPMC11031319 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature