4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara.

ABSTRACT:

Introduction

Cardiac dysfunction after sepsis the most common and severe sepsis-related organ failure. The severity of cardiac damage in sepsis patients was positively associated to mortality. It is important to look for drugs targeting sepsis-induced cardiac damage. Our previous studies found that 4-phenylbutyric acid (PBA) was beneficial to septic shock by improving cardiovascular function and survival, while the specific mechanism is unclear.

Objectives

We aimed to explore the specific mechanism and PBA for protecting cardiac function in sepsis.

Methods

The cecal ligation and puncture-induced septic shock models were used to observe the therapeutic effects of PBA on myocardial contractility and the serum levels of cardiac troponin-T. The mechanisms of PBA against s

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11031492 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature