Qualitative interviews of patients with COPD and muscle weakness enrolled in a clinical trial evaluating a new anabolic treatment: patient perspectives of disease experience, trial participation and outcome assessments.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) and muscle weakness can cause impaired physical function, significantly impacting patients' health-related quality of life (HRQoL). Loss of muscle strength is usually assessed through clinical and performance outcome (PerfO) assessments, which consists of tasks performed in a standardized manner, providing evidence of a patient's functional ability. However, evidence documenting the patient experience of COPD and muscle weakness is limited.

Methods

This two-stage qualitative study used semi-structured interviews in patients aged 45-80 years with COPD (post-bronchodilator forced expiratory volume in 1s [FEV₁]/forced vital capacity ratio < 0.70, and FEV₁% predicted of 30-80%) and muscle weakness. In

SUBMITTER: Tabberer M 

PROVIDER: S-EPMC11031513 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature