Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjogren's disease.

ABSTRACT: Childhood Sjögren's disease represents critically unmet medical needs due to a complete lack of immunological and molecular characterizations. This study presents key immune cell subsets and their interactions in the periphery in childhood Sjögren's disease. Here we show that single-cell RNA sequencing identifies the subsets of IFN gene-enriched monocytes, CD4⁺ T effector memory, and XCL1⁺ NK cells as potential key players in childhood Sjögren's disease, and especially in those with recurrent parotitis, which is the chief symptom prompting clinical visits from young children. A unique cluster of monocytes with type I and II IFN-related genes is identified in childhood Sjögren's disease, compared to the age-matched control. In vitro regulatory T cell functional assay d

SUBMITTER: Kim MC 

PROVIDER: S-EPMC11031574 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature