Endoplasmic reticulum stress-related genes as prognostic and immunogenic biomarkers in prostate cancer.

ABSTRACT:

Background

The metastasis and aggressive nature of prostate cancer (PCa) has become a major malignancy related threat that concerns men's health. The efficacy of immune monotherapy against PCa is questionable due to its lymphocyte-suppressive nature.

Method

Endoplasmic reticulum stress- (ERS-) and PCa-prognosis-related genes were obtained from the Molecular Signatures Database and the Cancer Genome Atlas database. The expression, prognosis and immune infiltration values of key genes were explored by "survival R package", "rms", "xCELL algorithm", and univariate-multivariate Cox and LASSO regression analyses. The "consensus cluster plus R package" was used for cluster analysis.

Result

As ERS-related genes, ERLIN2 and CDK5RAP3 showed significant expressional, prognostic

SUBMITTER: Wan L 

PROVIDER: S-EPMC11031923 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature