Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R.

ABSTRACT:

Background

Multiple neurodegenerative diseases are induced by the formation and deposition of protein aggregates. In particular, the microtubule-associated protein Tau leads to the development of so-called tauopathies characterized by the aggregation of hyperphosphorylated Tau within neurons. We recently showed that the constitutive activity of the serotonin receptor 7 (5-HT7R) is required for Tau hyperphosphorylation and aggregation through activation of the cyclin-dependent kinase 5 (CDK5). We also demonstrated physical interaction between 5-HT7R and CDK5 at the plasma membrane suggesting that the 5-HT7R/CDK5 complex is an integral part of the signaling network involved in Tau-mediated pathology.

Methods

Using biochemical, microscopic, molecular biological, computational a

SUBMITTER: Ackmann J 

PROVIDER: S-EPMC11031989 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature