Hippocampal subfield volumetric changes after radiotherapy for brain metastases.

ABSTRACT:

Background

Changes in the hippocampus after brain metastases radiotherapy can significantly impact neurocognitive functions. Numerous studies document hippocampal atrophy correlating with the radiation dose. This study aims to elucidate volumetric changes in patients undergoing whole-brain radiotherapy (WBRT) or targeted stereotactic radiotherapy (SRT) and to explore volumetric changes in the individual subregions of the hippocampus.

Method

Ten patients indicated to WBRT and 18 to SRT underwent brain magnetic resonance before radiotherapy and after 4 months. A structural T1-weighted sequence was used for volumetric analysis, and the software FreeSurfer was employed as the tool for the volumetry evaluation of 19 individual hippocampal subregions.

Results

The volume of

SUBMITTER: Holikova K 

PROVIDER: S-EPMC11032105 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature