Use of different anticholinergic scales and their correlation with anticholinergic symptom burden in a cohort of people living with HIV.

ABSTRACT:

Objectives

How to detect the clinical impact of anticholinergic (AC) burden in people with HIV (PWH) remains poorly investigated. We cross-sectionally described the prevalence and type of AC signs/symptoms and the screening accuracy of three AC scales in detecting their presence in a modern cohort of PWH.

Methods

We calculated AC Burden Scale (ABS), AC Risk Score (ARS) and AC Drug Score (ADS) in 721 adult PWH and recorded the presence of AC signs/symptoms over the previous 3 months. High AC risk was defined by ABS score ≥2, and ARS or ADS score ≥3. Comparisons among the scale were based on Cohen's inter-rater agreement, and their screening accuracy was assessed by receiver operating characteristics (ROC) curves and performance measures.

Results

We enrolled 721 PWH, of

SUBMITTER: Mazzitelli M 

PROVIDER: S-EPMC11032244 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature