Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling.

ABSTRACT: The ability of neurons to rapidly remodel their synaptic structure and strength in response to neuronal activity is highly conserved across species and crucial for complex brain functions. However, mechanisms required to elicit and coordinate the acute, activity-dependent structural changes across synapses are not well understood, as neurodevelopment and structural plasticity are tightly linked. Here, using an RNAi screen in Drosophila against genes affecting nervous system functions in humans, we uncouple cellular processes important for synaptic plasticity and synapse development. We find mutations associated with neurodegenerative and mental health disorders are 2-times more likely to affect activity-induced synaptic remodeling than synapse development. We report that while both

SUBMITTER: Chang YC 

PROVIDER: S-EPMC11032469 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature