Developmental trajectories of GABAergic cortical interneurons are sequentially modulated by dynamic <i>FoxG1</i> expression levels.

ABSTRACT: GABAergic inhibitory interneurons, originating from the embryonic ventral forebrain territories, traverse a convoluted migratory path to reach the neocortex. These interneuron precursors undergo sequential phases of tangential and radial migration before settling into specific laminae during differentiation. Here, we show that the developmental trajectory of FoxG1 expression is dynamically controlled in these interneuron precursors at critical junctures of migration. By utilizing mouse genetic strategies, we elucidate the pivotal role of precise changes in FoxG1 expression levels during interneuron specification and migration. Our findings underscore the gene dosage-dependent function of FoxG1, aligning with clinical observations of FOXG1 haploinsufficiency and

SUBMITTER: Miyoshi G 

PROVIDER: S-EPMC11032493 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature