Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity.

ABSTRACT: For nearly a century, evidence has accumulated indicating that the lateral hypothalamus (LH) contains neurons essential to sustain wakefulness. While lesion or inactivation of LH neurons produces a profound increase in sleep, stimulation of inhibitory LH neurons promotes wakefulness. To date, the primary wake-promoting cells that have been identified in the LH are the hypocretin/orexin (Hcrt) neurons, yet these neurons have little impact on total sleep or wake duration across the 24-h period. Recently, we and others have identified other LH populations that increase wakefulness. In the present study, we conducted microendoscopic calcium imaging in the LH concomitant with EEG and locomotor activity (LMA) recordings and found that a subset of LH neurons that express Ca²⁺/calmoduli

SUBMITTER: Heiss JE 

PROVIDER: S-EPMC11032496 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature