Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.

ABSTRACT:

Background

Structural disconnectivity was found to precede dementia. Global white matter abnormalities might also be associated with postoperative delirium (POD).

Methods

We recruited older patients (≥65 years) without dementia that were scheduled for major surgery. Diffusion kurtosis imaging metrics were obtained preoperatively, after 3 and 12 months postoperatively. We calculated fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK), and free water (FW). A structured and validated delirium assessment was performed twice daily.

Results

Of 325 patients, 53 patients developed POD (16.3%). Preoperative global MD (standardized beta 0.27 [95% confidence interval [CI] 0.21-0.32] p < 0.001) was higher in patients with POD. Preoperative global MK (-0.07 [95%

SUBMITTER: Fislage M 

PROVIDER: S-EPMC11032567 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature