Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles.

ABSTRACT: Exhausted CD8 T cells (T_EX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT⁺KLRG1⁺ T_EX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we found that the frequency of TIGIT⁺KLRG1⁺ T_EX is stable within an individual but differs across individuals in both T1D and healthy control (HC) cohorts. This TIGIT⁺KLRG1⁺ CD8 T_EX population shares an exhaustion-associated EOMES gene signature in HC, T1D, rheumatoid arthritis (RA), and cancer subjects, expresses multiple inhibitory receptors, and is hyporesponsive in vitro, together suggesting co-expression of TIGIT and KLRG1 may b

SUBMITTER: Long SA 

PROVIDER: S-EPMC11033422 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature