Training in Cortically Blinded Fields Appears to Confer Patient-Specific Benefit Against Retinal Thinning.

ABSTRACT:

Purpose

Damage to the adult primary visual cortex (V1) causes vision loss in the contralateral hemifield, initiating a process of transsynaptic retrograde degeneration (TRD). Here, we examined retinal correlates of TRD using a new metric to account for global changes in inner retinal thickness and asked if perceptual training in the intact or blind field impacts its progression.

Methods

We performed a meta-analysis of optical coherence tomography data in 48 participants with unilateral V1 stroke and homonymous visual defects who completed clinical trial NCT03350919. After measuring the thickness of the macular ganglion cell and inner plexiform layer (GCL-IPL) and the peripapillary retinal nerve fiber layer (RNFL), we computed individual laterality indices (LI) at baseline an

SUBMITTER: Fahrenthold BK 

PROVIDER: S-EPMC11033601 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature