The causal relationship between atopic dermatitis and brain cancer: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Atopic dermatitis ranks among the prevalent skin disorders. Research has indicated a potential association with brain cancer. Yet, establishing a direct causal relationship between atopic dermatitis and brain cancer continues to be challenging.

Materials and methods

We extracted single nucleotide polymorphisms (SNPs) significantly associated with atopic dermatitis (sample size = 382 254) at a genome-wide level from a large Finnish Genome-Wide Association Study (GWAS) dataset (n cases = 15 208, n controls = 367 046). Summary data for 372 622 cases of brain cancer (n cases = 606, n controls = 372 016) were obtained via the IEU Open GWAS database. We employed the Inverse Variance Weighted (IVW) method as our primary analytical approach for Mendelian Randomization (MR

SUBMITTER: Xin Y 

PROVIDER: S-EPMC11033834 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature