Multimodal exercise training to reduce frailty in people with multiple sclerosis: study protocol for a pilot randomized controlled trial.

ABSTRACT:

Background

Frailty, a syndrome characterized by decreased reserve and resistance to stressors across multiple physiologic systems, is highly prevalent in people living with multiple sclerosis (pwMS), independent of age or disability level. Frailty in MS is strongly associated with adverse clinical outcomes, such as falls, and may aggravate MS-related symptoms. Consequently, there is a pressing necessity to explore and evaluate strategies to reduce frailty levels in pwMS. The purpose of this pilot randomized controlled trial (RCT) will be to examine the feasibility and preliminary efficacy of a multimodal exercise training program to reduce frailty in pwMS.

Methods

A total of 24 participants will be randomly assigned to 6 weeks of multimodal exercise or to a waitlist control

SUBMITTER: Zanotto T 

PROVIDER: S-EPMC11034042 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature