M¹A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma.

ABSTRACT:

Background

N1-methyladenosine (m¹A), among the most common internal modifications on RNAs, has a crucial role to play in cancer development. The purpose of this study were systematically investigate the modification characteristics of m¹A in hepatocellular carcinoma (HCC) to unveil its potential as an anticancer target and to develop a model related to m¹A modification characteristics with biological functions. This model could predict the prognosis for patients with HCC.

Methods

An integrated analysis of the TCGA-LIHC database was performed to explore the gene signatures and clinical relevance of 10 m¹A regulators. Furthermore, the biological pathways regulated by m¹A modification patterns were investigated. The risk mo

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11034060 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature