In silico identification of drug targets and vaccine candidates against Bartonella quintana: a subtractive proteomics approach.

ABSTRACT:

Background

The availability of genes and protein sequences for parasites has provided valuable information for drug target identification and vaccine development. One such parasite is Bartonella quintana, a Gram-negative, intracellular pathogen that causes bartonellosis in mammalian hosts.

Objective

Despite progress in understanding its pathogenesis, limited knowledge exists about the virulence factors and regulatory mechanisms specific to B. quintana.

Methods and findings

To explore these aspects, we have adopted a subtractive proteomics approach to analyse the proteome of B. quintana. By subtractive proteins between the host and parasite proteome, a set of proteins that are likely unique to the parasite but absent in the host were identified. This analysis revealed

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC11034861 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature