Extensive Loss and Gain of Conserved Noncoding Elements During Early Teleost Evolution.

ABSTRACT: Conserved noncoding elements in vertebrates are enriched around transcription factor loci associated with development. However, loss and rapid divergence of conserved noncoding elements has been reported in teleost fish, albeit taking only few genomes into consideration. Taking advantage of the recent increase in high-quality teleost genomes, we focus on studying the evolution of teleost conserved noncoding elements, carrying out targeted genomic alignments and comparisons within the teleost phylogeny to detect conserved noncoding elements and reconstruct the ancestral teleost conserved noncoding elements repertoire. This teleost-centric approach confirms previous observations of extensive vertebrate conserved noncoding elements loss early in teleost evolution, but also reveals massive con

SUBMITTER: Iliopoulou E 

PROVIDER: S-EPMC11034925 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature