Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinoma.

ABSTRACT: Kidney clear cell renal cell carcinoma (KIRC) is also the most lethal subtype among all kidney cancer subtypes, posing a severe threat to public health. Therefore, it is crucial to identify new, reliable biomarkers in KIRC. Therefore, it is crucial to identify novel, reliable biomarkers associated with KIRC. We analyzed RNA sequence results from TCGA and several GEO datasets. The commonly deregulated gene, ALDOB, was found in multiple data and confirmed its important prognostic value. Subsequently, we explored the specific mechanism by which ALDOB regulates anti-tumor immunity through in vivo and in vitro experiments. We found that ALDOB may play a role in regulating tumor growth by regulating CD8⁺ T cell infiltration. This is consistent with the results of our immune infiltrati

SUBMITTER: Li XY 

PROVIDER: S-EPMC11035059 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature