Associations of Childhood Adiposity and Cardiometabolic Biomarkers With Adolescent PCOS.

ABSTRACT:

Objective

Polycystic Ovary Syndrome (PCOS) is common among females, with significant metabolic and reproductive comorbidities. We describe PCOS development in a pediatric population.

Methods

We assessed cardiometabolic biomarkers and adiposity at the midchildhood (mean 7.9 y), early teen (mean 13.1 y), and midteen (mean 17.8 y) visits among 417 females in the prospective Project Viva cohort. We defined PCOS via self-reported diagnosis or ovulatory dysfunction with hyperandrogenism in midlate adolescence. We used multivariable logistic regression to assess associations of metabolic and adiposity markers at each visit with PCOS.

Results

Adolescents with PCOS (n = 56, 13%) versus without had higher mean (SD) BMI z-score and truncal fat mass at the midchildhood (0.66 [0.9

SUBMITTER: Whooten RC 

PROVIDER: S-EPMC11035160 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature