Tet controls axon guidance in early brain development through glutamatergic signaling.

ABSTRACT: Mutations in ten-eleven translocation (TET) proteins are associated with human neurodevelopmental disorders. We find a function of Tet in regulating Drosophila early brain development. The Tet DNA-binding domain (Tet^AXXC) is required for axon guidance in the mushroom body (MB). Glutamine synthetase 2 (Gs2), a key enzyme in glutamatergic signaling, is significantly down-regulated in the Tet^AXXC brains. Loss of Gs2 recapitulates the Tet^AXXC phenotype. Surprisingly, Tet and Gs2 act in the insulin-producing cells (IPCs) to control MB axon guidance, and overexpression of Gs2 in IPCs rescues the defects of Tet^AXXC. Feeding Tet^AXXC with metabotropic glutamate recepto

SUBMITTER: Tran H 

PROVIDER: S-EPMC11035372 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature