ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.

ABSTRACT:

Background

Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions.

Methods

In animal studies, young adult wildtype and global Atf3 knockout mice unde

SUBMITTER: Pan JZ 

PROVIDER: S-EPMC11035380 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature