The macrophage STING-YAP axis controls hepatic steatosis by promoting the autophagic degradation of lipid droplets.

ABSTRACT:

Background and aims

The hallmark of NAFLD or hepatic steatosis is characterized by lipid droplet (LD) accumulation in hepatocytes. Autophagy may have profound effects on lipid metabolism and innate immune response. However, how innate immune activation may regulate the autophagic degradation of intracellular LDs remains elusive.

Approach and results

A mouse model of a high-fat diet-induced NASH was used in the myeloid-specific stimulator of interferon genes (STING) knockout or STING/yes-associated protein (YAP) double knockout mice. Liver injury, lipid accumulation, lipid droplet proteins, autophagic genes, chromatin immunoprecipitation coupled with massively parallel sequencing, and RNA-Seq were assessed in vivo and in vitro . We found that high-fat diet-induced oxidative s

SUBMITTER: Yang T 

PROVIDER: S-EPMC11035483 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature