Multidimensional features of sporadic Creutzfeldt-Jakob disease in the elderly: a case report and systematic review.

ABSTRACT:

Background

As a rare neurodegenerative disease, sporadic Creutzfeldt-Jakob disease (sCJD) is poorly understood in the elderly populace. This study aims to enunciate the multidimensional features of sCJD in this group.

Methods

A case of probable sCJD was reported in a 90-year-old Chinese man with initial dizziness. Then, available English literature of the elderly sCJD cases (aged 80 years and over) was reviewed and analyzed. Patients (15 cases) were subdivided and compared geographically.

Results

In the elderly sCJD cohort, the onset age was 84.9 ± 4.5 years and the median disease duration was 6.8 months, with respiratory infection/failure as the commonest death cause. Various clinical symptoms were identified, with cognitive disorder (86.7%) as the commonest typical

SUBMITTER: Liao J 

PROVIDER: S-EPMC11035806 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature