Pan-cancer analysis of SLC2A family genes as prognostic biomarkers and therapeutic targets.

ABSTRACT:

Background

The major facilitator superfamily glucose transporters (GLUTs), encoded by solute carrier 2A (SLC2A) genes, mediate the transmembrane movement and uptake of glucose. To satisfy the improved energy demands, glycolysis flux is increased in cancers compared with healthy tissues. Multiple diseases, including cancer, have been associated with GLUTs. Nevertheless, not much research has been done on the functions of SLC2As in pan-cancer prognosis or their clinical treatment potential.

Methods

The SLC2A family genes' level of expression and prognostic values were analyzed in relation to pan-cancer. We then examined the association among SLC2As expression and TME, Stemness score, clinical characteristics, immune subtypes, and drug sensitivity. We merged bioinformatics anal

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11036058 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature