The conjugates of 5'-deoxy-5-fluorocytidine and hydroxycinnamic acids - synthesis, anti-pancreatic cancer activity and molecular docking studies.

ABSTRACT: New amide conjugates 1-6 of hydroxycinnamic acids (HCA) and 5'-deoxy-5-fluorocytidine (5-dFCR), the prodrug of 5-fluorouracil (5-FU), were synthesized and tested in vitro against pancreatic cancer lines (PDAC). The compounds showed slightly higher efficacy against primary BxPC-3 cells (IC₅₀ values of 14-45 μM) than against metastatic AsPC-1 (IC₅₀ values of 37-133 μM), and similar to that of 5-FU for both PDAC lines. Compound 1, which has a para-(acetyloxy)coumaroyl substituent, was found to be the most potent (IC₅₀ = 14 μM) with a selectivity index of approximately 7 to normal dermal fibroblasts (IC₅₀ = 96 μM). The potential pharmacological profiles were discussed on the basis of the ADME data. Docking to the carboxylesterase CES2 s

SUBMITTER: Cybulski M 

PROVIDER: S-EPMC11036175 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature